Thursday, April 7, 2011

Biologics

Free eBooks on Biologics

What are BIOLOGICS?  Let WIKIPEDIA define it for you.

 This is the first book comprising all relevant aspects for the clinical application of biologics. All biologics currently approved for clinical use are described in a standardized way concentrating on practically relevant aspects such as contra-indications or monitoring needs. The "differential therapy" with biologics namely in the fields of dermatology, rheumatology, gastroenterology, and neurology is described in detail and summarized in treatment algorithms. Shorter sections on the biotechnology behind the biologics as well as safety, regulatory, and pharmaco-economic aspects complement the more clinically-oriented central chapters.


Biologics in Inflammatory Bowel Disease  (Oxford American Pocket Notes)
Scott Plevy, Publisher: OUP USA; 1 Spi edition | ISBN 10: 0195391187 | 2011 | File type: PDF | 63 pages | 1.2 mb.  
Biologic therapies include:(1) naturally occurring or modified biologic compounds such as vaccines (live, live attenuated, or killed microorganisms), hormone extracts, and blood products;(2) recombinant proteins or peptides—for example, granulocyte macrophage colony stimulating factor and growth hormone;(3) monoclonal antibodies and fusion proteins; and (4) antisense oligonucleotides to nucleic acids. These biologic therapies, which are targeted towards specific disease mechanisms, have the potential to provide more effective and safe treatments for human diseases. Clinical trials have demonstrated that inhibition of the cytokine tumour necrosis factor α(TNF) and inhibition of the selective adhesion molecules α4 integrin and α4β7 integrin are effective in the treatment of various forms of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD). It is also clear that drug toxicity related to biologic therapy, including hypersensitivity, serum sickness, autoimmunity, infection, and immunogenicity may occur.

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